I do believe there is an art to resigning.

It is never a good idea to leave poorly.

You never know when you may need the person again in the future.

Nor do you know if they have friends at other institutions/hospitals.

Plus you may need them as your referee for a new job.

Keep things professional.

 I recommend following follow some of these suggestions:

• write a short, professional and polite resignation letter. Include the role you are resigning from and what your last day of work will be. You may want to add a sentence about your reasons for resigning but you do not have to include this. 
• ask the manager to speak with you in private at their convenience.
• do not tell other people you are resigning before you meet with your manager. If they hear rumours it is not nice.
• be discrete with other job interviews prior to resigning.
• make eye contact during the resignation. Yes, it is uncomfortable but being professional and present for the resignation is the most professional way to manage yourself. 
• be polite. Highlight some positive experiences you have had on the ward and express your appreciation for the professional opportunities you enjoyed. 
• if your manager tries to pry out reasons for your resignation try to remain positive. There is no need to get negative unless you feel you can frame things in a way which won’t leave the manager feeling attacked. 
• close the meeting by confirming the next steps. That is, when your last day will be.
• work until your last day. It may be easy to start cruising out of the job. But respect your colleagues and your patients and give your all until you leave.